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menA [2020-06-18 10:04:44]
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menA [2020-06-18 10:04:44]

probable 1,4-dihydroxy-2-naphthoate octaprenyltransferase
Locus
BSU_38490
Isoelectric point
9.32
Molecular weight
33.68 kDa
Protein length
311 aa Sequence Blast
Gene length
936 bp Sequence Blast
Function
biosynthesis of menaquinone
Product
probable 1,4-dihydroxy-2-naphthoate octaprenyltransferase
Essential
yes
E.C.
2.5.1.74
Synonyms
ywaB,ipa-6d
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
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Categories containing this gene/protein

  • Metabolism → Additional metabolic pathways → Biosynthesis of cofactors → Biosynthesis of menaquinone
  • Groups of genes → Essential genes
  • Groups of genes → Membrane proteins

    • Gene

    Coordinates
    3,950,726 3,951,661

    Phenotypes of a mutant

  • essential PubMed

    • The protein

    Catalyzed reaction/ biological activity

  • 1,4-dihydroxy-2-naphthoate + all-trans-polyprenyl diphosphate + H+ --> 2-demethylmenaquinol + CO2 + diphosphate (according to UniProt)

    • Protein family

  • MenA family (single member, according to UniProt)

    • Structure

  • 3BYV (from Toxoplasma gondii, 30% identity in a 25% fragment) PubMed

    • Localization

  • cell membrane (according to UniProt)

    • Expression and Regulation

    Operons

    Genes
    menA
    Description
    PubMed

    Regulation

  • the leader mRNA is processed by RNase Y, this requires the YmcA-YlbF-YaaT complex PubMed
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    Biological materials

    Mutant

  • MGNA-B217 (ywaB::erm), available at the NBRP B. subtilis, Japan

    • References

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